Genome Mining for Antimicrobial Compounds in Wild Marine Animals-Associated Enterococci.

ABSTRACT: New ecosystems are being actively mined for new bioactive compounds. Because of the large amount of unexplored biodiversity, bacteria from marine environments are especially promising. Further, host-associated microbes are of special interest because of their low toxicity and compatibility with host health. Here, we identified and characterized biosynthetic gene clusters encoding antimicrobial compounds in host-associated enterococci recovered from fecal samples of wild marine animals remote from human-affected ecosystems. Putative biosynthetic gene clusters in the genomes of 22 Enterococcus strains of marine origin were predicted using antiSMASH5 and Bagel4 bioinformatic software. At least one gene cluster encoding a putative bioactive compound precursor was identified in each geno

SUBMITTER: Prichula J 

PROVIDER: S-EPMC8229437 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature