Description and Analysis of Cytokine Storm in Registered COVID-19 Clinical Trials: A Systematic Review.

ABSTRACT: The purpose of this systematic review was to describe the characteristics of clinical trials that focused on COVID-19 patients with cytokine release syndrome (CRS) and the variability in CRS definitions. Two authors independently searched three clinical trial registries and included interventional clinical trials on COVID-19 hospitalized patients that required at least one elevated inflammatory biomarker. Relevant data, including the type and cutoff of the measured biomarker, oxygen/respiratory criteria, fever, radiologic criteria, and medications, were summarized. A total of 47 clinical trials were included. The included studies considered the following criteria: oxygen/respiratory criteria in 42 trials (89%), radiologic criteria in 29 trials (62%), and fever in 6 trials (18%). Serum ferr

SUBMITTER: Eljaaly K 

PROVIDER: S-EPMC8229812 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature