Prospecting Biomarkers for Diagnostic and Therapeutic Approaches in Pythiosis.

ABSTRACT: Pythiosis, whose etiological agent is the oomycete Pythium insidiosum, is a life-threatening disease that occurs mainly in tropical and subtropical countries, affecting several animal species. It is frequently found in horses in Brazil and humans in Thailand. The disease is difficult to diagnose because the pathogen's hyphae are often misdiagnosed as mucoromycete fungi in histological sections. Additionally, there is no specific antigen to use for rapid diagnosis, the availability of which could improve the prognosis in different animal species. In this scenario, we investigated which P. insidiosum antigens are recognized by circulating antibodies in horses and humans with pythiosis from Brazil and Thailand, respectively, using 2D immunoblotting followed by mass spectrometry

SUBMITTER: Chechi JL 

PROVIDER: S-EPMC8229905 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature