The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols.

ABSTRACT:

Background

Polyphenols are secondary metabolites produced by plants to defend themselves from environmental stressors. We explored the effect of Wolffia globosa 'Mankai', a novel cultivated strain of a polyphenol-rich aquatic plant, on the metabolomic-gut clinical axis in vitro, in-vivo and in a clinical trial.

Methods

We used mass-spectrometry-based metabolomics methods from three laboratories to detect Mankai phenolic metabolites and examined predicted functional pathways in a Mankai artificial-gut bioreactor. Plasma and urine polyphenols were assessed among the 294 DIRECT-PLUS 18-month trial participants, comparing the effect of a polyphenol-rich green-Mediterranean diet (+1240 mg/polyphenols/day, provided by Mankai, green tea and walnuts) to a walnuts-enriched (+4

SUBMITTER: Yaskolka Meir A 

PROVIDER: S-EPMC8229908 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature