Variation in Human Milk Composition Is Related to Differences in Milk and Infant Fecal Microbial Communities.

ABSTRACT: Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into a smaller number of community state types based on sh

SUBMITTER: Pace RM 

PROVIDER: S-EPMC8230061 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature