Current Knowledge of Long Non-Coding RNA HOTAIR in Breast Cancer Progression and Its Application.

ABSTRACT: Breast cancer is one of the most devastating cancers with high morbidity and mortality in females worldwide. Breast tumorigenesis and further development present great uncertainty and complexity, and efficient therapeutic approaches still lack. Accumulating evidence indicates HOX transcript antisense intergenic RNA (HOTAIR) is dysregulated in cancers and has emerged as a novel hotspot in the field. In breast cancer, aberrant HOTAIR expression is responsible for advanced tumor progression by regulating multifarious signaling pathways. Besides, HOTAIR may act as competitive endogenous RNA to bind to several microRNAs and suppress their expressions, which can subsequently upregulate the levels of targeted downstream messenger RNAs, thereby leading to further cancer progression. In addition, H

SUBMITTER: Shi Y 

PROVIDER: S-EPMC8230351 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature