Metabolomic Study of High-Fat Diet-Induced Obese (DIO) and DIO Plus CCl₄-Induced NASH Mice and the Effect of Obeticholic Acid.

ABSTRACT: The pathophysiology of nonalcoholic fatty liver disease (NAFLD) is a complex process involving metabolic and inflammatory changes in livers and other organs, but the pathogenesis is still not well clarified. Two mouse models were established to study metabolic alteration of nonalcoholic fatty liver and nonalcoholic steatohepatitis, respectively. The concentrations of metabolites in serum, liver and intestine content were measured by the AbsoluteIDQ^® p180 Kit (Biocrates Life Sciences, Innsbruck, Austria). Multivariate statistical methods, pathway analysis, enrichment analysis and correlation analysis were performed to analyze metabolomic data. The metabolic characteristics of liver, serum and intestine content could be distinctly distinguished from each group, indicating the occu

SUBMITTER: Zhu N 

PROVIDER: S-EPMC8230384 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature