Emerging Role of microRNAs and Long Non-Coding RNAs in Sjogren's Syndrome.

ABSTRACT: Sjögren's Syndrome (SS) is a chronic autoimmune inflammatory disease. It is considered a multifactorial pathology, in which underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to development. The epigenetic regulations represent a link between genetic predisposition and environmental factors. Recent studies suggested a regulatory role for non-coding RNAs in critical biological and disease processes. Among non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play a critical role in the post-transcriptional mRNA expression, forming a complex network of gene expression regulation. This review aims to give an overview of the latest studies that have investigated the role of miRNAs and lncRNAs in the SS. We included papers that investi

SUBMITTER: De Benedittis G 

PROVIDER: S-EPMC8230573 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature