Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4+ Cancers.

ABSTRACT: The accumulated molecular knowledge about human cancer enables the identification of multiple cell surface markers as highly specific therapeutic targets. A proper tumor targeting could significantly avoid drug exposure of healthy cells, minimizing side effects, but it is also expected to increase the therapeutic index. Specifically, colorectal cancer has a particularly poor prognosis in late stages, being drug targeting an appropriate strategy to substantially improve the therapeutic efficacy. In this study, we have explored the potential of the human albumin-derived peptide, EPI-X4, as a suitable ligand to target colorectal cancer via the cell surface protein CXCR4, a chemokine receptor overexpressed in cancer stem cells. To explore the potential use of this ligand, self-assembling prote

SUBMITTER: Cano-Garrido O 

PROVIDER: S-EPMC8230831 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature