Brain Metastases in HER2-Positive Breast Cancer: Current and Novel Treatment Strategies.

ABSTRACT: Development of brain metastases can occur in up to 30-50% of patients with breast cancer, representing a significant impact on an individual patient in terms of survival and quality of life. Patients with HER2-positive breast cancer have an increased risk of developing brain metastases; however, screening for brain metastases is not currently recommended due to the lack of robust evidence to support survival benefit. In recent years, several novel anti-HER2 agents have led to significant improvements in the outcomes of HER2-positive metastatic breast cancer. Despite these advances, brain and leptomeningeal metastases from HER2-positive breast cancer remain a significant cause of morbidity and mortality, and their optimal management remains an unmet need. This review presents an update on t

SUBMITTER: Garcia-Alvarez A 

PROVIDER: S-EPMC8230933 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature