Protocol for a randomised controlled trial comparing two CPAP levels to prevent extubation failure in extremely preterm infants.

ABSTRACT:

Introduction

Respiratory distress syndrome is a complication of prematurity and extremely preterm infants born before 28 weeks' gestation often require endotracheal intubation and mechanical ventilation. In this high-risk population, mechanical ventilation is associated with lung injury and contributes to bronchopulmonary dysplasia. Therefore, clinicians attempt to extubate infants as quickly and use non-invasive respiratory support such as nasal continuous positive airway pressure (CPAP) to facilitate the transition. However, approximately 60% of extremely preterm infants experience 'extubation failure' and require reintubation. While CPAP pressures of 5-8 cm H2O are commonly used, the optimal CPAP pressure is unknown, and higher pressures may be beneficial in avoiding extubation

SUBMITTER: Kidman AM 

PROVIDER: S-EPMC8230987 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature