Neurogenic and Neuroprotective Potential of Stem/Stromal Cells Derived from Adipose Tissue.

ABSTRACT: Currently, the number of stem-cell based experimental therapies in neurological injuries and neurodegenerative disorders has been massively increasing. Despite the fact that we still have not obtained strong evidence of mesenchymal stem/stromal cells' neurogenic effectiveness in vivo, research may need to focus on more appropriate sources that result in more therapeutically promising cell populations. In this study, we used dedifferentiated fat cells (DFAT) that are proven to demonstrate more pluripotent abilities in comparison with standard adipose stromal cells (ASCs). We used the ceiling culture method to establish DFAT cells and to optimize culture conditions with the use of a physioxic environment (5% O₂). We also performed neural differentiation tests and assessed the neur

SUBMITTER: Figiel-Dabrowska A 

PROVIDER: S-EPMC8231154 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature