Biphenylalkoxyamine Derivatives-Histamine H₃ Receptor Ligands with Butyrylcholinesterase Inhibitory Activity.

ABSTRACT: Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can contribute to a desired pharmacological effect in these complex illnesses. Histamine H₃ receptors (H₃Rs) play an important role in the brain, influencing the release of important neurotransmitters, such as acetylcholine. Compounds blocking their activity can increase the level of these neurotransmitters. Cholinesterases (acetyl- and butyrylcholinesterase) are responsible for the hydrolysis of acetylcholine and inactivation of the neurotransmitter. Increased activity of these enzymes, especially bu

SUBMITTER: Lazewska D 

PROVIDER: S-EPMC8231170 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature