Ontology highlight
ABSTRACT:
SUBMITTER: Salerno L
PROVIDER: S-EPMC8231349 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Salerno Loredana L Vanella Luca L Sorrenti Valeria V Consoli Valeria V Ciaffaglione Valeria V Fallica Antonino N AN Canale Vittorio V Zajdel Paweł P Pignatello Rosario R Intagliata Sebastiano S
Journal of enzyme inhibition and medicinal chemistry 20211201 1
In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its <i>in vitro</i> chemical and enzymatic hydrolysis stability. Predicted <i>in silico</i> physicochemical properties of the newly synthesised hybrid (<b>3</b>) demonstrated a drug-like profile with suitable Absorption, Distribution, Metabolism, and Excretion (ADME) properties and low toxic liabilities. Preliminary cytotoxicity evaluation to ...[more]