Impact of Susceptibility to Injectable Antibiotics on the Treatment Outcomes of Mycobacterium abscessus Pulmonary Disease.

ABSTRACT:

Background

Current guidelines recommend a susceptibility-based regimen for Mycobacterium abscessus subspecies abscessus pulmonary disease (MAB-PD), but the evidence is weak. We aimed to investigate the association between treatment outcomes and in vitro drug susceptibility to injectable antibiotics in MAB-PD patients.

Methods

We enrolled MAB-PD patients treated with intravenous amikacin and beta-lactams for ≥4 weeks at 4 referral hospitals in Seoul, South Korea. Culture conversion and microbiological cure at 1 year were evaluated based on susceptibility to injectable antibiotics among patients treated with those antibiotics for ≥2 weeks.

Results

A total of 82 patients were analyzed. The mean age was 58.7 years, and 65.9% were women. Sputum culture conver

SUBMITTER: Park Y 

PROVIDER: S-EPMC8231371 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature