Chemokines gene expression in the prefrontal cortex of depressed suicide victims and normal control subjects.

ABSTRACT: Abnormalities of neuroinflammation have been implicated in the pathogenesis of depression and suicide. This is primarily based on the observation that cytokines, which are major inflammatory molecules and play an important role in depression and suicide, are increased in both serum and in postmortem brain of depressed and suicidal subjects. Another class of immune mediators are chemokines which are primarily involved in chemotactic properties and trafficking of immune cells in the central nervous system (CNS). Chemokines also play an important role in CNS function. Whereas chemokines have been studied in the serum of depressed and suicidal patients, their role in brain of depressed or suicidal subjects is relatively unexplored. We studied the gene expression of several chemokines in the pr

SUBMITTER: Pandey GN 

PROVIDER: S-EPMC8231709 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature