Polyphenol Supplementation Reverses Age-Related Changes in Microglial Signaling Cascades.

ABSTRACT: Microglial activity in the aging neuroimmune system is a central player in aging-related dysfunction. Aging alters microglial function via shifts in protein signaling cascades. These shifts can propagate neurodegenerative pathology. Therapeutics require a multifaceted approach to understand and address the stochastic nature of this process. Polyphenols offer one such means of rectifying age-related decline. Our group used mass spectrometry (MS) analysis to explicate the complex nature of these aging microglial pathways. In our first experiment, we compared primary microglia isolated from young and aged rats and identified 197 significantly differentially expressed proteins between these groups. Then, we performed bioinformatic analysis to explore differences in canonical signaling cascades

SUBMITTER: Jalloh A 

PROVIDER: S-EPMC8232085 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature