Sex-Differences in Traumatic Brain Injury in the Absence of Tau in Drosophila.

ABSTRACT: Traumatic brain injuries, a leading cause of death and disability worldwide, are caused by a severe impact to the head that impairs physiological and psychological function. In addition to severity, type and brain area affected, brain injury outcome is also influenced by the biological sex of the patient. Traumatic brain injury triggers accumulation of Tau protein and the subsequent development of Tauopathies, including Alzheimer's disease and Chronic traumatic encephalopathy. Recent studies report differences in Tau network connections between healthy males and females, but the possible role of Tau in sex-dependent outcome to brain injury is unclear. Thus, we aimed to determine if Tau ablation would alleviate sex dependent outcomes in injured flies. We first assessed motor function and su

SUBMITTER: Shah EJ 

PROVIDER: S-EPMC8232113 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature