Plasma ctDNA Response Is an Early Marker of Treatment Effect in Advanced NSCLC.

ABSTRACT: Plasma circulating tumor DNA (ctDNA) analysis is routine for genotyping of advanced non-small-cell lung cancer (NSCLC); however, early response assessment using plasma ctDNA has yet to be well characterized.

Materials and methods

Patients with advanced EGFR-mutant NSCLC across three phase I NCI osimertinib combination trials were analyzed in this study, and an institutional cohort of patients with KRAS-, EGFR-, and BRAF-mutant advanced NSCLC receiving systemic treatment was used for validation. Plasma was collected before treatment initiation and serially before each cycle of therapy, and key driver mutations in ctDNA were characterized by droplet digital polymerase chain reaction. Timing of plasma versus imaging response was compared in a separate cohort

SUBMITTER: Cheng ML 

PROVIDER: S-EPMC8232122 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature