Gene Expression Profiling Reveals New Pathways and Genes Associated with Visna/Maedi Viral Disease.

ABSTRACT: Visna/Maedi virus (VMV) is a lentivirus that infects the cells of the monocyte/macrophage lineage in sheep, goats and wild ruminants. Infection with VMV causes a multisystemic inflammatory disorder, which includes pneumonia, encephalitis, mastitis or arthritis. The immune response to VMV infection is complex, and the infection and pathogenesis of this virus are not totally characterized yet. In this work, a gene expression microarray was used to identify the differentially expressed genes in VMV infection and disease development by comparing sheep with different serologic status and with presence of VM-characteristic clinical lesions. The expression profile analysis has revealed many interesting genes that may be associated with the viral infection process. Among them, the OXT gene appeare

SUBMITTER: Abendano N 

PROVIDER: S-EPMC8232142 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature