Differential Expression of BOC, SPOCK2, and GJD3 Is Associated with Brain Metastasis of ER-Negative Breast Cancers.

ABSTRACT:

Background

Brain metastasis is considered one of the major causes of mortality in breast cancer patients. To invade the brain, tumor cells need to pass the blood-brain barrier by mechanisms that are partially understood. In primary ER-negative breast cancers that developed brain metastases, we found that some of the differentially expressed genes play roles in the T cell response. The present study aimed to identify genes involved in the formation of brain metastasis independently from the T cell response.

Method

Previously profiled primary breast cancer samples were reanalyzed. Genes that were found to be differentially expressed were confirmed by RT-PCR and by immunohistochemistry using an independent cohort of samples.

Results

BOC, SPOCK2, and GJD3 we

SUBMITTER: Pedrosa RMSM 

PROVIDER: S-EPMC8232218 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature