A Signature-Based Classification of Gastric Cancer That Stratifies Tumor Immunity and Predicts Responses to PD-1 Inhibitors.

ABSTRACT: Gastric cancer is a leading cause of cancer-related deaths with considerable heterogeneity among patients. Appropriate classifications are essential for prognosis prediction and individualized treatment. Although immunotherapy showed potential efficacy in a portion of patients with gastric cancer, few studies have tried to classify gastric cancer specifically based on immune signatures. In this study, we established a 3-subtype cluster with low (C_LIM), medium (C_MIM), and high (C_HIM) enrichment of immune signatures based on immunogenomic profiling. We validated the classification in multiple independent datasets. The C_HIM subtype exhibited a relatively better prognosis and showed features of "hot tumors", including low tumor purity, high stromal c

SUBMITTER: Li S 

PROVIDER: S-EPMC8232232 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature