Pathogen Moonlighting Proteins: From Ancestral Key Metabolic Enzymes to Virulence Factors.

ABSTRACT: Moonlighting and multitasking proteins refer to proteins with two or more functions performed by a single polypeptide chain. An amazing example of the Gain of Function (GoF) phenomenon of these proteins is that 25% of the moonlighting functions of our Multitasking Proteins Database (MultitaskProtDB-II) are related to pathogen virulence activity. Moreover, they usually have a canonical function belonging to highly conserved ancestral key functions, and their moonlighting functions are often involved in inducing extracellular matrix (ECM) protein remodeling. There are three main questions in the context of moonlighting proteins in pathogen virulence: (A) Why are a high percentage of pathogen moonlighting proteins involved in virulence? (B) Why do most of the canonical functions of these moon

SUBMITTER: Franco-Serrano L 

PROVIDER: S-EPMC8232316 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature