The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology.

ABSTRACT: Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic bone formation. In recent decades, their key role has broadly expanded beyond bone physiology and pathology. Nowadays, the BMP pathway is considered an important player in vascular signaling. Indeed, mutations in genes encoding different components of the BMP pathway cause various severe vascular diseases. Their signaling contributes to the morphological, functional and molecular heterogeneity among endothelial cells in different vessel types such as arteries, veins, lymphatic vessels and capillaries within different organs. The BMP pathway is a remarkably fine-tuned pathway. As a result, its signaling output in the vessel wall critically depends on the cellular c

SUBMITTER: Ponomarev LC 

PROVIDER: S-EPMC8232321 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature