Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults.

ABSTRACT:

Background

Circadian disturbances are commonly seen in people with Alzheimer's disease and have been reported in individuals without symptoms of dementia but with Alzheimer's pathology. We aimed to assess the temporal relationship between circadian disturbances and Alzheimer's progression.

Methods

We did a prospective cohort study of 1401 healthy older adults (aged >59 years) enrolled in the Rush Memory and Aging Project (Rush University Medical Center, Chicago, IL, USA) who had been followed up for up to 15 years. Participants underwent annual assessments of cognition (with a battery of 21 cognitive performance tests) and motor activities (with actigraphy). Four measures were extracted from actigraphy to quantify daily and circadian rhythmicity, which were amplitude of 24-h

SUBMITTER: Li P 

PROVIDER: S-EPMC8232345 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature