Strategies to Develop Potent Oncolytic Viruses and Enhance Their Therapeutic Efficacy.

ABSTRACT: Despite advancements in cancer therapy that have occurred over the past several decades, successful treatment of advanced malignancies remains elusive. Substantial resources and significant efforts have been directed toward the development of novel therapeutic modalities to improve patient outcomes. Oncolytic viruses (OVs) are emerging tools with unique characteristics that have attracted great interest in developing effective anticancer treatment. The original attraction was directed toward selective replication and cell-specific toxicity, two unique features that are either inherent to the virus or could be conferred by genetic engineering. However, recent advancements in the knowledge and understanding of OVs are shifting the therapeutic paradigm toward a greater focus on their immunomo

SUBMITTER: Moaven O 

PROVIDER: S-EPMC8232397 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature