Designing microbial communities to maximize the thermodynamic driving force for the production of chemicals.

ABSTRACT: Microbial communities have become a major research focus due to their importance for biogeochemical cycles, biomedicine and biotechnological applications. While some biotechnological applications, such as anaerobic digestion, make use of naturally arising microbial communities, the rational design of microbial consortia for bio-based production processes has recently gained much interest. One class of synthetic microbial consortia is based on specifically designed strains of one species. A common design principle for these consortia is based on division of labor, where the entire production pathway is divided between the different strains to reduce the metabolic burden caused by product synthesis. We first show that classical division of labor does not automatically reduce the metabolic bu

SUBMITTER: Bekiaris PS 

PROVIDER: S-EPMC8232427 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature