Clinical Profile and Treatment Response in Patients with CASPR2 Antibody-Associated Neurological Disease.

ABSTRACT:

Background

The clinical spectrum of contactin-associated protein-like 2 (CASPR2) antibody-associated disease is wide and includes Morvan syndrome. Studies describing treatment and long-term outcome are limited.

Aims

We report the clinical profile and emphasize response to treatment and long-term outcome in eight patients with CASPR2-antibody-associated disease.

Methods

Clinical, radiological, electrophysiological, treatment, follow-up, and outcome data were collected by retrospective chart review.

Results

Clinical manifestations included Morvan syndrome (n = 7) and limbic encephalitis (n = 1). None of the patients were positive for LGI1 antibody. Associated features included myasthenia (n = 1), thymoma (n = 1), and dermatological man

SUBMITTER: Shivaram S 

PROVIDER: S-EPMC8232480 | biostudies-literature | 2021 Mar-Apr

REPOSITORIES: biostudies-literature