DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.

ABSTRACT:

Background

Blood pressure often rises with aging, but exact mechanisms are still not completely understood. With aging, the level of proinflammatory cytokines increases in T lymphocytes. Prostaglandin D₂, a proresolution mediator, suppresses Type 1 T helper (Th1) cytokines through D-prostanoid receptor 1 (DP1). In this study, we aimed to investigate the role of the prostaglandin D₂/DP1 axis in T cells on age-related hypertension.

Methods

To clarify the physiological and pathophysiological roles of DP1 in T cells with aging, peripheral blood samples were collected from young and older male participants, and CD4⁺ T cells were sorted for gene expression, prostaglandin production, and Western blot assays. Mice blood pressure was quantified by inv

SUBMITTER: Kong D 

PROVIDER: S-EPMC8232565 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature