Integrated Systems Analysis of Mixed Neuroglial Cultures Proteome Post Oxycodone Exposure.

ABSTRACT: Opioid abuse has become a major public health crisis that affects millions of individuals across the globe. This widespread abuse of prescription opioids and dramatic increase in the availability of illicit opioids have created what is known as the opioid epidemic. Pregnant women are a particularly vulnerable group since they are prescribed for opioids such as morphine, buprenorphine, and methadone, all of which have been shown to cross the placenta and potentially impact the developing fetus. Limited information exists regarding the effect of oxycodone (oxy) on synaptic alterations. To fill this knowledge gap, we employed an integrated system approach to identify proteomic signatures and pathways impacted on mixed neuroglial cultures treated with oxy for 24 h. Differentially expressed pro

SUBMITTER: Guda RS 

PROVIDER: S-EPMC8232620 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature