Transcriptomic and Genetic Associations between Alzheimer's Disease, Parkinson's Disease, and Cancer.

ABSTRACT: Alzheimer's (AD) and Parkinson's diseases (PD) are the two most prevalent neurodegenerative disorders in human populations. Epidemiological studies have shown that patients suffering from either condition present a reduced overall risk of cancer than controls (i.e., inverse comorbidity), suggesting that neurodegeneration provides a protective effect against cancer. Reduced risks of several site-specific tumors, including colorectal, lung, and prostate cancers, have also been observed in AD and PD. By contrast, an increased risk of melanoma has been described in PD patients (i.e., direct comorbidity). Therefore, a fundamental question to address is whether these associations are due to shared genetic and molecular factors or are explained by other phenomena, such as flaws in epidemiological

SUBMITTER: Fores-Martos J 

PROVIDER: S-EPMC8232649 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature