Cell-Penetrating Peptides: Applications in Tumor Diagnosis and Therapeutics.

ABSTRACT: Since their identification over twenty-five years ago, the plethora of cell-penetrating peptides (CPP) and their applications has skyrocketed. These 5 to 30 amino acid in length peptides have the unique property of breaching the cell membrane barrier while carrying cargoes larger than themselves into cells in an intact, functional form. CPPs can be conjugated to fluorophores, activatable probes, radioisotopes or contrast agents for imaging tissues, such as tumors. There is no singular mechanism for translocation of CPPs into a cell, and therefore, many CPPs are taken up by a multitude of cell types, creating the challenge of tumor-specific translocation and hindering clinical effectiveness. Varying strategies have been developed to combat this issue and enhance their diagnostic potential b

SUBMITTER: Stiltner J 

PROVIDER: S-EPMC8232808 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature