Whole-Exome Sequencing Analysis of Human Semen Quality in Russian Multiethnic Population.

ABSTRACT: The global trend toward the reduction of human spermatogenic function observed in many countries, including Russia, raised the problem of extensive screening and monitoring of male fertility and elucidation of its genetic and ethnic mechanisms. Recently, whole-exome sequencing (WES) was developed as a powerful tool for genetic analysis of complex traits. We present here the first Russian WES study for identification of new genes associated with semen quality. The experimental 3 × 2 design of the WES study was based on the analysis of 157 samples including three ethnic groups-Slavs (59), Buryats (n = 49), and Yakuts (n = 49), and two different semen quality groups-pathozoospermia (n = 95) and normospermia (n = 62). Additionally, our WES study group was negative f

SUBMITTER: Kolmykov S 

PROVIDER: S-EPMC8232892 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature