Supramolecular Polymer Hydrogels for Drug-Induced Tissue Regeneration.

ABSTRACT: Supramolecular polymers self-assemble into nanofibers, micelles, and other nanostructures through weak noncovalent interactions between subunits. Such systems possess attractive properties for use in a variety of practical settings such as energy, sustainability, and healthcare. In regenerative medicine, a common approach involves implanting a supramolecular material containing cell and growth factor binding motifs directly into a diseased or traumatized tissue defect, whereupon it interacts with and/or recruits components of the biological system to induce tissue healing. Here we introduce a supramolecular therapeutic in which tissue regeneration is orchestrated by a supramolecular polymer prodrug implanted subcutaneously in a remote tissue. Our approach exploits a hydrophobic small-molec

SUBMITTER: Cheng J 

PROVIDER: S-EPMC8232973 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature