Statin use and mortality in COVID-19 patients: Updated systematic review and meta-analysis.

ABSTRACT:

Background and aims

Statin therapy is administered to patients with high cardiovascular risk. These patients are also at risk for severe course of coronavirus disease 2019 (COVID-19). Statins exhibit not only cardioprotective but also immunomodulatory and anti-inflammatory effects. This study performed a systematic review of published evidence regarding statin treatment and COVID-19 related mortality.

Methods

A systematic PubMed/Embase search was performed from February 10, 2020 until March 05, 2021 for studies in COVID-19 patients that reported adjusted hazard or odds ratio for death in statin users versus non-users.

Results

22 studies fulfilled the inclusion criteria and were included in the systematic review. Meta-analysis of 10 studies (n = 41,807, weighted age 56

SUBMITTER: Kollias A 

PROVIDER: S-EPMC8233054 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature