LncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression.

ABSTRACT: lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified GAU1 as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ranking percentile = 99.75%, P < 10^-50), which is coexpressed with the potential oncogene GALNT8 (Spearman rho = 0.67, P = 2.44 × 10^-23, TCGA dataset n = 184). Experimental data revealed that GAU1 regulates the expression of GALNT8. The overexpression of either GAU1 or GALNT8 significantly promotes the cell cycle and proliferation of CRC cell lines and correlates with poor prognosis in patients with CRC (P = 3.04 × 10^-2), while silencing of GA

SUBMITTER: Tang X 

PROVIDER: S-EPMC8233076 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature