Matching in cluster randomized trials using the Goldilocks Approach.

ABSTRACT: In group or cluster-randomized trials (GRTs), matching is a technique that can be used to improve covariate balance. When baseline data are available, we suggest a strategy that can be used to achieve the desired balance between treatment and control groups across numerous potential confounding variables. This strategy minimizes the overall within-pair Mahalanobis distance; and involves iteratively: 1) making pairs that minimize the distance between pairs of clusters with respect to potentially confounding variables; 2) visually assessing the potential effects of these pairs and resulting possible randomizations; and 3) reweighting variables of selecting weights to make pairs of clusters. In step 2, we plot the between-arm differences with a parallel-coordinates plot. Investigators can com

SUBMITTER: Sturdevant SG 

PROVIDER: S-EPMC8233129 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature