Comparing Articaine brands: A randomized non-inferiority controlled trial.

ABSTRACT:

Introduction

The substitution of reference drugs for similar, new or existing drugs in the market is a dilemma present in daily dental procedures. In order to decide whether or not to adopt a new drug in relation to the reference, a clinical trial can provide the necessary evidence.

Methods

A total of 179 healthy volunteers (18-25 years) requiring extraction of mandibular third molars completed the study. Subjects were randomized into 4 groups: right, left, Arteek-SP and Septanest. Allocations consisted of 4% Articaine hydrochloride with 1:10000 epinephrine. The primary aim of this randomized controlled trial was to determine whether the test drug Arteek-SP was noninferior by a margin of 10% in the proportion of patients with total absence of pain, compared to the reference

SUBMITTER: Arboleda-Toro D 

PROVIDER: S-EPMC8233148 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature