The impact of body mass index on breast cancer incidence among women at increased risk: an observational study from the International Breast Intervention Studies.

ABSTRACT:

Background

We investigated the association between body mass index (BMI) and breast cancer risk in women at increased risk of breast cancer receiving tamoxifen or anastrozole compared with placebo using data from the International Breast Cancer Intervention Studies [IBIS-I (tamoxifen) and IBIS-II (anastrozole)].

Methods

Baseline BMI was calculated from nurse assessed height and weight measurements for premenopausal (n = 3138) and postmenopausal (n = 3731) women in IBIS-I and postmenopausal women in IBIS-II (n = 3787). The primary endpoint was any breast cancer event (invasive and ductal carcinoma in situ). We used Cox proportional hazards regression to calculate hazard ratios (HRs) for risk after adjustment for covariates.

Results

There were 582 (IBIS-I) and 248 (IBIS

SUBMITTER: Smith SG 

PROVIDER: S-EPMC8233270 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature