Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes.

ABSTRACT: Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes are insufficiently characterized, presenting a barrier in translational research. Based on analyses of acutely purified astrocytes, serum-free cultures of primary astrocytes, and xenografted chimeric mice, we find extensive conservation in astrocytic gene expression between human and mouse samples. However, the genes involved in defense response and metabolism show species-specific differences. Human astrocytes exhibit greater susceptibility to oxidative stress than mouse astrocytes, due to differences in mitochondrial physiology and detoxificat

SUBMITTER: Li J 

PROVIDER: S-EPMC8233314 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature