A Retrospective Analysis of 287 Patients Undergoing Prophylactic Radiation Therapy for the Prevention of Heterotopic Ossification.

ABSTRACT:

Purpose

Heterotopic ossification (HO) is a potentially disabling disorder of ectopic bone formation secondary to orthopedic surgery or trauma. In this retrospective analysis we evaluated the outcomes of patients who received radiation therapy (RT) for HO prophylaxis.

Methods and materials

A total of 287 patients who received RT for HO prophylaxis at a major trauma center from 2007 to 2018 were analyzed. Data collected included types of injury, surgery, time intervals between key events, development of postprophylaxis HO, and secondary malignancies. Associations between various factors and the risk of developing HO were analyzed. Kaplan-Meier analysis was used to estimate failure rates.

Results

The most common indication for RT was traumatic acetabular fracture (83.3%)

SUBMITTER: Freije SL 

PROVIDER: S-EPMC8233464 | biostudies-literature | 2021 May-Jun

REPOSITORIES: biostudies-literature