Spatially fractionated stereotactic body radiation therapy (Lattice) for large tumors.

ABSTRACT:

Purpose

Stereotactic body radiation therapy (SBRT) has demonstrated clinical benefits for patients with metastatic and/or unresectable cancer. Technical considerations of treatment delivery and nearby organs at risk can limit the use of SBRT in large tumors or those in unfavorable locations. Spatially fractionated radiation therapy (SFRT) may address this limitation because this technique can deliver high-dose radiation to discrete subvolume vertices inside a tumor target while restricting the remainder of the target to a safer lower dose. Indeed, SFRT, such as GRID, has been used to treat large tumors with reported dramatic tumor response and minimal side effects. Lattice is a modern approach to SFRT delivered with arc-based therapy, which may allow for safe, high-quality SBRT for

SUBMITTER: Duriseti S 

PROVIDER: S-EPMC8233471 | biostudies-literature | 2021 May-Jun

REPOSITORIES: biostudies-literature