The Counteracting Effects of Demography on Functional Genomic Variation: The Roma Paradigm.

ABSTRACT: Demographic history plays a major role in shaping the distribution of genomic variation. Yet the interaction between different demographic forces and their effects in the genomes is not fully resolved in human populations. Here, we focus on the Roma population, the largest transnational ethnic minority in Europe. They have a South Asian origin and their demographic history is characterized by recent dispersals, multiple founder events, and extensive gene flow from non-Roma groups. Through the analyses of new high-coverage whole exome sequences and genome-wide array data for 89 Iberian Roma individuals together with forward simulations, we show that founder effects have reduced their genetic diversity and proportion of rare variants, gene flow has counteracted the increase in mutational loa

SUBMITTER: Font-Porterias N 

PROVIDER: S-EPMC8233508 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature