Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection.

ABSTRACT: Severe viral infections, including SARS-COV-2, could trigger disruption of the balance between pro-oxidant and antioxidant mediators; the magnitude of which could reflect the severity of infection and lung injury. Using publicly available COVID-19 transcriptomic datasets, we conducted an in-silico analyses to evaluate the expression levels of 125 oxidative stress genes, including 37 pro-oxidant genes, 32 oxidative-responsive genes, and 56 antioxidant genes. Seven oxidative stress genes were found to be upregulated in whole blood and lung autopsies (MPO, S100A8, S100A9, SRXN1, GCLM, SESN2, and TXN); these genes were higher in severe versus non-severe COVID-19 leucocytes. Oxidative genes were upregulated in inflammatory cells comprising macrophages and CD8⁺ T cells isolated from b

SUBMITTER: Saheb Sharif-Askari N 

PROVIDER: S-EPMC8233550 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature