Universal Constraints on Protein Evolution in the Long-Term Evolution Experiment with Escherichia coli.

ABSTRACT: Although it is well known that abundant proteins evolve slowly across the tree of life, there is little consensus for why this is true. Here, I report that abundant proteins evolve slowly in the hypermutator populations of Lenski's long-term evolution experiment with Escherichia coli (LTEE). Specifically, the density of all observed mutations per gene, as measured in metagenomic time series covering 60,000 generations of the LTEE, significantly anticorrelates with mRNA abundance, protein abundance, and degree of protein-protein interaction. The same pattern holds for nonsynonymous mutation density. However, synonymous mutation density, measured across the LTEE hypermutator populations, positively correlates with protein abundance. These results show that universal constraints on protein ev

SUBMITTER: Maddamsetti R 

PROVIDER: S-EPMC8233687 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature