CD101 genetic variants modify regulatory and conventional T cell phenotypes and functions.

ABSTRACT: We recently reported that the risk of sexually acquired HIV-1 infection is increased significantly by variants in the gene encoding CD101, a protein thought to modify inflammatory responses. Using blood samples from individuals with and without these variants, we demonstrate that CD101 variants modify the prevalence of circulating inflammatory cell types and show that CD101 variants are associated with increased proinflammatory cytokine production by circulating T cells. One category of CD101 variants is associated with a reduced capacity of regulatory T cells to suppress T cell cytokine production, resulting in a reduction in the baseline level of immune quiescence. These data are supported by transcriptomics data revealing alterations in the intrinsic regulation of a

SUBMITTER: Richert-Spuhler LE 

PROVIDER: S-EPMC8233694 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature