Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge.

ABSTRACT: Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to morphology, immunophenotyping, germline and somatic cytogenetic and genetic abnormalities. Over recent decades, outcomes have greatly improved, although survival rates remain around 70% and the relapse rate is high, at around 30%. Cytogenetics is an important factor for diagnosis and indication of prognosis. The main cytogenetic abnormalities are referenced in the current WHO classification of acute myeloid leukemia, where there is an indication for risk-adapted therapy. The aim of this article is to provide an updated review of cytogenetics in pediatric AML, describing well-known WHO entities, as well as new subgroups and germline mutations with therapeutic implications. We describe the main chromosomal ab

SUBMITTER: Quessada J 

PROVIDER: S-EPMC8233729 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature