New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation.

ABSTRACT: Src family kinases (SFKs) are key regulators of cell proliferation, differentiation, and survival. The expression of these non-receptor tyrosine kinases is strongly correlated with cancer development and tumor progression. Thus, this family of proteins serves as an attractive drug target. The activation of SFKs can occur via multiple signaling pathways, yet many of them are poorly understood. Here, we summarize the current knowledge on G protein-coupled receptor (GPCR)-mediated regulation of SFKs, which is of considerable interest because GPCRs are among the most widely used pharmaceutical targets. This type of activation can occur through a direct interaction between the two proteins or be allosterically regulated by arrestins and G proteins. We postulate that a rearrangement of binding m

SUBMITTER: Berndt S 

PROVIDER: S-EPMC8233884 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature