Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues.

ABSTRACT: In recent years, biofluid has been considered a promising source of non-invasive biomarkers for health monitoring and disease diagnosis. However, the expression consistency between biofluid and human tissue, which is fundamental to RNA biomarker development, has not been fully evaluated. In this study, we collected expression profiles across 53 human tissues and five main biofluid types. Utilizing the above dataset, we uncovered a globally positive correlation pattern between various biofluids (including blood, urine, bile, saliva and stool) and human tissues. However, significantly varied biofluid-tissue similarity levels and tendencies were observed between mRNA and lncRNA. Moreover, a higher correlation was found between biofluid types and their functionally related and anatomically clo

SUBMITTER: Sun R 

PROVIDER: S-EPMC8234006 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature