KMDATA: a curated database of reconstructed individual patient-level data from 153 oncology clinical trials.

ABSTRACT: We created a database of reconstructed patient-level data from published clinical trials that includes multiple time-to-event outcomes such as overall survival and progression-free survival. Outcomes were extracted from Kaplan-Meier (KM) curves reported in 153 oncology Phase III clinical trial publications identified through a PubMed search of clinical trials in breast, lung, prostate and colorectal cancer, published between 2014 and 2016. For each trial that met our search criteria, we curated study-level information and digitized all reported KM curves with the software Digitizelt. We then used the digitized KM survival curves to estimate (possibly censored) patient-level time-to-event outcomes. Collections of time-to-event datasets from completed trials can be used to support the choice

SUBMITTER: Fell G 

PROVIDER: S-EPMC8234134 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature